OrthoInspector is a specialized bioinformatics software suite and online portal designed for the rapid inference and analysis of orthology and paralogy relationships among proteins across the tree of life. Developed by the Laboratory of Bioinformatics and Integrative Genomics (LBGI) in France, it functions as a highly scalable system used by researchers to explore the evolutionary histories of genes, annotate functions, and perform comparative genomics. Core Mechanics & Algorithm
OrthoInspector operates by parsing massive sequence similarity datasets to detect gene evolutionary lineages:
Input-Driven Prediction: It uses a high-performance heuristic algorithm that processes all-versus-all BLAST alignments.
Inparalog Grouping: The algorithm generates putative “inparalog” groups (genes duplicated after a given speciation event).
Contradiction Detection: It conducts pairwise comparisons between these groups to eliminate false positives and cleanly isolate true orthologs (genes separated by a speciation event). Database Structure
The OrthoInspector Web Portal hosts precomputed data spanning thousands of organisms across three distinct structural tiers: OrthoInspector – About
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